Cataract Clear

Breakthrough Cataract Reversal in a Drop

BENEFITS:

• May reverse cataract
• Prevents cataract.
• Reduces photophobia and sensitivity to glare in 88.9% of cases.
• Provides general antioxidant protection of the eye.
• Prevents senile cataract-related blindness in 99.99% of cases
• Improves lens transmissibility.

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Lenses grow from outside in, meaning that the cells at the centre are the oldest. As the cells age, they are subjected to oxidation and a process called glycation in which sugars combine with proteins leading to cataract, which is the clouding of the normally clear lens of the eye. In a normal eye, light focuses precisely on the retina but in an eye with cataract, light instead scatters throughout the eye.

Apart from aging, cataract can be a result of: trauma (injury to the eye, contact of the eye with chemical substance), cumulative ultraviolet radiation damage from sun exposure, heredity, poor nutrition, smoking, high blood pressure, kidney disease, diabetes retinopathy, and the long-term use of corticosteroids. The clouding of the lens leading to a painless blurring of vision, can progress to complete blindness .Other symptoms include: glare, or light sensitivity, poor night vision, double vision in one eye, needing brighter light to read, fading or yellowing of colours.

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The most common treatment for cataract is surgery, which is the most commonly performed surgical operation in the world today (1.35 million eye surgeries per year). While cataract surgery is generally recognised as being one of the safest operations, there is a significant complication rate. 30% to 50% of patients develop the opacification of the posterior lens capsule within two years and require further laser treatments, which indirectly have a negative impact on the financial income of these individuals and their families. Approximately 27,000 individuals in the world each year develop serious complications, which include: post-surgery infections, retinal detachments, and corneal oedema.

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Today, NG4L CATARACT CLEAR is an alternative and complementary treatment therapy with N-acetylcarnosine as the main potent ingredient that has been shown to prevent and reverse the cross-linking of the lens proteins that leads to opacification and impairs vision.

Other applications: N-acetylcarnosine may also be useful for the following conditions: Presbyopia; Open-angle primary glaucoma (in combination with beta-blockers); Corneal disorders; Computer vision syndrome; Eye strain; Eye strain; Ocular inflammation; Blurred vision; Dry eye syndrome; Retinal diseases; Vitreous opacities and lesions; Complications of diabetes mellitus and other systemic diseases; Contact lens difficulties, particularly with soft contact lenses. Not only do the lubricants in the Can-C or N-acetylcarnosine eye-drop help to make wearing contact lenses more comfortable, but n-acetylcarnosine is also believed to reduce the build-up of lactic acid in the eye, thus enabling the lens to be left safely in the eye for longer.

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HOW N-ACETYLCARNOSINE WORKS

The body is made up largely of proteins. As we age, proteins tend to undergo destructive changes due largely to oxidation and interactions with sugars and aldehydes. These interrelated protein modifications include oxidation, carbonylation, cross-linking, glycation, and advanced glycation end product (AGE) formation. These processes contribute to the aging process.

More specifically, cataracts are formed by the glycation of proteins. Glycation occurs when proteins react with sugars and form advanced glycation end products (AGEs). AGEs physically alter proteins, DNA, and lipids, changing their chemical properties. The result of this reaction leads to the discoloration of the eye lens to yellow and brown, which consequently results in the impairment of vision.

Studies show that carnosine is effective against all these forms of protein modification. When the N-acetylcarnosine eye drops are administered, carnosine competes for the glycating agent on the molecule, and protects cellular structures against aldehydes, slowing and helping to prevent proteins from cross-linking and becoming a cataract, and also breaking existing cross-links.

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Presentation: Each carton of NG4L Cataract Clear contains two (5ml vials) and each 5ml vial contains approximately 65-drops. Using two drops in one eye twice daily, one box of NG4L Cataract Clear will last approximately four weeks for one eye. (NOTE: Lasts half as long if treating both eyes)

NG4L Cataract Clear Ingredients: N-Acetyl-Carnosine (NAC) 1.0% (approved by IVP); Glycerin (lubricant) 1.0%; Carboxymethylcellulose sodium (lubricant) 0.3%

 Excipients: Sterile Water (Ophthalmic Grade Isotonic Solution, pH 6.3 to 6.5); Buffers: Potassium Bicarbonate and Boric Acid; Purified Benzyl Alcohol (Preservative) 0.3%

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Storage: Keep in cool dry environment and do not expose to extreme temperatures. All open vials should be discarded after 30 days.

Directions:
1 or 2 drops in each eye 1-4 times a day or as directed by a physician. Please read the enclosed product insert carefully. For cataract, apply a total of 4 drops daily to each affected eye. For general health improvement apply 2 drops daily to each eye. For better results, NG4L CATARACT CLEAR should be taking for a period of 4-6 months.

Eye Drop Installation Instructions:

• Wash your hands with soap and water.
• Lean head back and look toward the ceiling with both eyes open. If you have neck problems, lie down or use a tilt-back chair.
• Pull lower lid down with one hand to enlarge the opening.
• Hold bottle in other hand and turn directly upside down. Then carefully line up with the eye.
• Gently squeeze to instill “one drop” then gently close the eye for 60 seconds. The tip of the vial should never touch the eye.
• Do not blink or reopen the eye for 60-seconds. Repeat this procedure, if a second drop is used. Closing the eye allows each drop to be absorbed into the eye tissue. Blinking, even one or two times, will pump most of the solution out of the eye. Wait 5 – 10 minutes or even an hour or more between applications to the same eye to prevent overflow of the product and to ensure maximum benefit.

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 How does N-Acetylcarnosine actually work to reverse cataracts?

Firstly, it is now known that cataract is the result of elevating levels of “ascorbate oxidation” or oxidative stress due in part to oxygen free radicals in the eye. This unchecked oxidation results in the cross linking of lens proteins, which is a slow glycosylation process. Cross linking of the lens proteins eventually causes a yellowing or browning pigmentation of the lens or (lens opacification) limiting the amount of light that reaches the retina, resulting in worsening vision.

This degenerative process occurs and advances as the natural antioxidant supply in the eye diminishes. Critical antioxidant supplies are continually being tapped from the eye, for protection against; over exposure to ultraviolet light, against toxins and chemicals present in the air we breathe, the food we eat, against the hours we spend looking at our computer screens, and so on.

Researchers recently learned that the healthy human eye contains high levels of the natural antioxidant carnosine. Interestingly the eyes of those suffering from degenerative ocular diseases such as cataracts were found to be grossly deficient in this essential ocular antioxidant.

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The prime ingredient in NG4L Cataract Clear is N-acetylcarnosine, a highly specific intraocular released form of carnosine which acts as both a stabilizer and carrier for the di-peptide L-carnosine, safely delivering it into the aqueous humour of the eye, (the fluid area surrounding the lens). It is here, that the bio-identical antioxidant becomes most active in its ability to act as a natural and highly effective anti-oxidant. Important Note: Years of research were spent to identify a specific purity level of N-acetylcarnosine (NAC) that that would ensure both safety and optimal results.

Dr. Mark Babizhayev of Innovative Vision Products (IVP), also makes it quite clear that common L-carnosine if used in a non- approved n-acetylcarnosine formulation will not be of much use in the treatment of senile-cataract. This is because there are many synthesized “carnosines” and their biological and medicinal activity strongly varies depending upon how and where they are sourced. For example, if carnosine is extracted from meat muscle substances, the biological and anti-oxidant activity is very low. This is presumably due to the contamination of the “pure” carnosine substance by heavy metal salts and proteins and other related impurities.

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 It is very complicated to effectively purify carnosine chromatographically, as the compound chelates divalent metal ions very heavily and the biological and anti-oxidant activities cannot be regenerated during the purification procedures. In conclusion, there were many forms of carnosine, which were abandoned, in the Russian studies because of their lack of anti-cataract and anti-oxidant ability in the human eye. However, Innovative Vision Products (IVP), in conjunction with their Japanese partner and manufacturer, have researched, developed and patented a highly specific purity factor of n-acetylcarnosine which has excellent biological activity and has been proven effective in controlled human lens studies.

 So what is the difference between Carnosine, L-Carnosine and N-acetylcarnosine?

There are different forms of carnosine; the best known is L-Carnosine and much has been published as to its impressive antioxidant and anti-aging benefits. N-acetylcarnosine which is a specific intraocular released form of carnosine is significantly different from L-carnosine although related. In addition to the proprietary, highly specific purity level of the n-acetylcarnosine that is used in Can-C™, the acetylation process is what makes n-acetyl-carnosine suitable and stable in the eye. Unfortunately L-carnosine by itself, when applied topically, is easily broken down by a dipeptidase enzyme that is present in blood plasma known as carnosinase, and therefore is not deliverable into the aqueous humour of the eye. Furthermore, there are indications that a topical eye application of L-carnosine by itself may release the toxic compound, histamine, (which can severely promote oxidation reactions and therefore could cause other eye-problems with long-term use. This means that L-carnosine by itself is not suitable for eye-drop use as it is either ineffective, or could even be damaging to some tissues over time.

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The acetylation component of IVP N-acetylcarnosine (Can-C™) makes it very stable and highly resistant to carnosinase. Additionally this stabilized compound protects against oxidative stress in the lipid phase of biological cellular membranes and in the aqueous environment by a gradual intraocular turnover into L-carnosine maintaining a longer active therapeutic concentration of carnosine directly within the aqueous humour and the lens of the treated eye. Again the purity level of this particular n-acetylcarnosine is critical to its effectiveness.

 (IVP) N-Acetylcarnosine Action(s):

• Anti-glycation properties reverse cross lining of lens proteins.
• Protects against oxidative stress both in the lipid phase of cellular membranes and in the aqueous environment.
• Protects structural proteins of the lens/ alpha-crystalline, from the free-radical induced oxidation process.
• Deliverable and stable at the cellular level

Can-C™ is a proprietary form of N-acetylcarnosine, a highly specific intraocular released form of carnosine which acts as both a stabilizer and carrier for safe delivery into the aqueous humor of the eye. Once delivered into the aqueous humor this bio-identical molecule becomes highly active in the reduction of free radicals, oxidative stress and lens glycosylation.

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Manufactured in a GMP certified, pharmaceutical facility which meets ISO 9001:2000 and ISO 13485:2003 standards for the design/formulation and manufacture of sterile contact lens solution and pharmaceutical solutions. Exp. September 2012

Can-C™ Ingredients:

• N-Acetyl-Carnosine (NAC) 1.0% (approved by IVP)
• Glycerin (lubricant) 1.0%
• Carboxymethylcellulose sodium (lubricant) 0.3%

 Excipients:

• Sterile Water (Ophthalmic Grade Isotonic Solution, pH 6.3 to 6.5)
• Buffers: Potassium Bicarbonate and Boric Acid
• Purified Benzyl Alcohol (Preservative) 0.3%

Eye Drop Installation Instructions:

• Wash your hands with soap and water.
• Look toward the ceiling with both eyes open.
• Pull lower lid down with one hand to enlarge the opening.
• Hold bottle in other hand and turn directly upside down. Then carefully line up with the eye.
• Gently squeeze to instill “one drop” then gently close the eye for 60 seconds. The tip of the vial should never touch the eye.
• Wait 5 – 10 minutes or even an hour or more between applications to the same eye to prevent overflow of the product and to ensure maximum benefit.
• For cataract, apply a total of 4 drops daily to each affected eye. For general health improvement apply 2 drops daily to each eye.

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Each carton of Can-C™ contains two (5ml vials) and each 5ml vial contains approximately 65-drops. Using two drops in one eye twice daily, one box of Can-C™ will last approximately four weeks for one eye. (NOTE: Lasts half as long if treating both eyes)

Storage: Keep in cool dry environment and do not expose to extreme temperatures. All open vials should be discarded after 30 days.